What are precautions for administration of Transamin to patients with chronic renal failure?

Because Transamin is excreted via the kidney, care must be taken not to administer it at high doses for long periods. The drug has a wide range of doses, it should be administered to such patients at lower doses while observing patient’s conditions.

What are precautions for intravenous injection of Transamin?

It needs to be injected slowly in the same manner for injection of calcium preparations. Although Transamin is an easy-to-use drug which rarely entails adverse reactions, it may cause nausea, vomiting, or transient decrease in blood pressure when injected rapidly. If any of these adverse reactions occured, the injection should be discontinued to give the patient a rest. These adverse reactions are just transient ones and patients will recover from them soon. When the relationship between the incidence of nausea/vomitting and injection of Transamin was investigated using dog models, the injection speed had a larger influence on the incidence of nausea than the concentration of the drug. When 30 mg/kg of Transamin was intravenously injected into normal healthy dogs, there was no effect. When it was injected in a dose of 40 to 300 mg/kg, however, a vomitory effect was observed depending on the dose. It was found that induction of vomiting could be relieved by reducing the injection speed.

What is the initial dose of Transamin injection for bleeding?

The adequate dose of the drug is 10 to 30 mg per kilogram of body weight. Normally, 20 mg/kg is used. For example, the average dose of the drug for a patient who weighs 50 kg is 1,000 mg, but it can be increased according to the amount of bleeding.

Why is it necessary to administer Transamin before surgery?

Abnormal bleeding may occur suddenly during or after operation. Although Transamin is a quick-acting medicine for abnormal bleeding, it is administered before operation to prevent the risk of bleeding beforehand. Doctors used to administer hemostatic drugs after abnormal bleeding occured, but it is an old custom whose time has passed. As preoperative therapy, Transamin is often orally administered. When oral administration is not possible, the drug is injected.

What kinds of diseases are the main targets of Transamin?

Transamin is effective for systemic diseases and diseases possibly associated with the accentuation of local fibrinolysis.

Typical diseases or conditions which possibly enhance fibrinolysis

Transient accentuation of fibrinolysis

Injection of adrenalin, pyrogenic substances, stress, transfusion-associated shock, and surgery of the uterus, lung, pancreas, or prostate gland

Persistent accentuation of fibrinolysis

Liver cirrhosis, leukemia, aplastic anemia, thrombocytopenia, idiopathic renal hemorrhage, prostate cancer, prostatic hypertroph, systemic metastasis of cancer, pancreatic diseases, thyroid diseases, pneumonia, pulmonary suppuration, lung tumor, burn injury, and allergic reaction

Secondary accentuation of fibrinolysis

Early separation of the placenta, dead fetus in uterus, amniotic fluid embolism, acute promyelocytic leukemia, systemic metastasis of stomach cancer, purpura fulminans, thrombolytic purpura, and disseminated intravascular coagulation syndrome (DIC)

What kinds of diseases are the main targets of Transamin?

Transamin is effective for systemic diseases and diseases possibly associated with the accentuation of local fibrinolysis.

Typical diseases or conditions which possibly enhance fibrinolysis

Transient accentuation of fibrinolysis

Injection of adrenalin, pyrogenic substances, stress, transfusion-associated shock, and surgery of the uterus, lung, pancreas, or prostate gland

Persistent accentuation of fibrinolysis

Liver cirrhosis, leukemia, aplastic anemia, thrombocytopenia, idiopathic renal hemorrhage, prostate cancer, prostatic hypertroph, systemic metastasis of cancer, pancreatic diseases, thyroid diseases, pneumonia, pulmonary suppuration, lung tumor, burn injury, and allergic reaction

Secondary accentuation of fibrinolysis

Early separation of the placenta, dead fetus in uterus, amniotic fluid embolism, acute promyelocytic leukemia, systemic metastasis of stomach cancer, purpura fulminans, thrombolytic purpura, and disseminated intravascular coagulation syndrome (DIC)

What is the pharmacokinetic of Transamin after administration?

Pharmacokinetic parameters of Transamin after oral administration or injection are follows :

Tranexamic acid is rapidly absorbed when orally administered to healthy adult volunteers in a single dose of 250 or 500 mg, intramuscularly administered in a dose of 500 mg, or intravenously administered in a dose of 1,000 mg. Approximately 40 to 70% (when orally administered in a dose of 250 or 500 mg) or 80% and 76% (when intramuscularly administered in a dose of 500 mg and intravenously administered in a dose of 1,000 mg) respectively) of the drug are excreted into urine as unchanged compounds within 24 hours after administration.