What is the minimum amount of bleeding during a delivery that is treated as abnormal bleeding?

The amount of bleeding during a delivery mainly means the total amount of bleeding during the period from a delivery to 2 hours after that. In general, when the amount of bleeding is 500 ml or more, it is defined as abnormal bleeding.

During a delivery, bleeding occurs from the separation of the placenta and from the injured area of soft birth canal. The greater part of the bleeding is from the separation of the placenta. Because there are plenty of plasminogen activators associated with fibrinolysis in the uterus, Transamin, an antiplasminic agent that inhibits the action of the plasminogen activators, is effective.

Major treatments for afterbirth bleeding (third stage of labor) are classified into two types : mechanical, surgical method and pharmacological, medical method. Among pharmacological, medical treatments are administration of a uterotonic (quick-acting), administration of a hemostatic agent, and blood transfusion. Uterotonic agents have a strong hemostatic effect and used routinely.

Oral administration of Transamin before childbirth or intravenous injection of Transamin immediately before the third stage of labor is effective in inhibiting the amount of bleeding and preventing abnormal bleeding.